An insight into hypothesized biological mechanisms contributing to the Flash effect
نویسندگان
چکیده
In recent years, FLASH radiotherapy (FLASH RT) has gained attention in preclinical studies as a potential advancement cancer treatment. The great advantage of RT is the ultra-fast, high doses delivery that have similar or greater effect on cells while sparing normal, healthy tissue surrounding tumor site. This known effect. However, currently, there are not enough vitro and vivo data to transpose human trials. mini review summarizes available electron beam FLASH, focusing possible mechanisms Current focused various types cancer, including lung glioblastoma, uterus adenocarcinoma, cervix carcinoma, prostate melanoma, breast head neck squamous cell colon adenocarcinoma. Several hypotheses been proposed explain biological contributing selective effect, differences between production reactive oxygen species free radicals, limitation Fenton reaction caused by Fe 2+ / 3+ levels cells, impaired DNA damage repair occurring cancer.
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ژورنال
عنوان ژورنال: Frontiers in Physics
سال: 2023
ISSN: ['2296-424X']
DOI: https://doi.org/10.3389/fphy.2023.1201708